Purified Vitexin Compound 1 Serves as a Promising Antineoplastic Agent in Ovarian Cancer

Ovarian cancer is a common gynecologic aggressive neoplasm. The mortality of ovarian top among malignancies due to the insidious onset, atypical early symptoms, and chemoresistance. Therefore, it urgent seek another promising treatment for cancer. Purified vitexin compound 1 (VB1) kind neolignan from seed traditional Chinese herb vitex negundo that possessed diverse pharmacological effects. VB1 can exhibit anti-neoplastic activities against various cancers. However, role in has not been elaborated, mechanism unknown. aim this study was investigate therapeutic effects cells both vitro vivo , along with molecular action. In VB-1 effectively suppress proliferation, induce apoptosis, block cell cycle at G2/M phase concentration dependent manner cells. Western blot assay showed apoptosis via upregulating expression cleaved-caspase3 through P21. Meanwhile, inhibit tumor growth xenograft mouse model. Our research indicated significantly exert its may represent new class agents therapy.